correlation between cervical length by transvaginal sonography at16

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correlation between cervical length by transvaginal sonography at16
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References:
1.
cervix in asymptomatic pregnant women: review
Botsis D, Makrakis E, PapagianniV. The value of
of the literature. Ultrasound Obstet Gynecol
cervical length and plasma proMMP-9 levels for
2002;19(3): 302-11.
Downloaded from umj.umsu.ac.ir at 4:06 IRST on Thursday March 9th 2017
the prediction of preterm delivery in pregnant
2.
3.
5.
Hauth L, Gilstrap K. Preterm Birth .Williams's
Obstetrics. 22nd ed. New York: McGraw-Hill s;
108-12.
2005. P.860-2.
Emily A, DeFranco DO. Improving the screening
10. MohamadJafari R, Najafian M. Transvaginal
accuracy for preterm labor: is the combination of
Sonography And Cervical Length Changes In
fetal
Normal Pregnancy. Pak J Med Sci 2009;25(2):
fibronectin
and
cervical
length
in
symptomatic patients a useful predictor of preterm
222-5.
birth? A systematic review. Am J Obstet Gynecol
11. Gramellini
S, Molina
E, Berretta
R, Vadora E. Transvaginalsonographic cervical
Ekele B, Airede L. Cervical cerclage for
length changes during normal pregnancy. J
prevention of preterm delivery in women with
Ultrasound Med 2002 ;21(3): 227-32.
12. Palma RS, Fonseca MM, Stein NR, Schmidt AP,
1849-53.
Magalhaes JA. Relation of cervical length at 22-
Ness A, Visintine J, Ricci E, Berghella V. Does
24 weeks of gestation. Brazilian J Med Biolog Res
knowledge of cervical length and fetal fibronectin
2004; 5: 737-44.
affect management of women with threatened
13. Iams JD, Goldenberg RL, Meis PJ, Mercer BM,
preterm labor? A randomized trial. Am J Obstet
Moawad A, Das A, et al. The length of the cervix
Gynecol 2007;197(4): 426-7.
and the risk of spontaneous preterm delivery. New
Sotiriadis
A, Kavvadias
A, Papatheodorou
England J Med 1996; 334(9): 567-72.
S, Paraskevaidis E, Makrydimas G. The value of
14. Cook CM, Ellwood DA. The cervix as a predictor
serial cervical length measurements for the
of preterm delivery in 'at-risk' women. Ultrasound
prediction of threatened preterm labour. Eur J
Obstet Gyneco 2000;15(2): 109-13.
Naim
A, Haberman
S, Burgess
T, Navizedeh
risk of preterm labor. Am J Obstet Gynecol
2002;186(5): 887-9.
Tekesin
A, Kühnert
15. Hibbard JU, Tart M, Moawad AH. Cervical length
at 16-22 week gestation and risk for preterm
delivery. Obstetrics Gynecol 2000;96(6): 972-8.
16. Carvalho MH, Bittar RE, BrizotMde L, Bicudo C,
Zugaib M. Prediction of preterm delivery in the
I, Hellmeyer
L, Heller
M, Schmidt
S.
G, Römer
Evaluation
of
second trimester. Obstet Gynecolo 2005;105(3):
532-6.
quantitative ultrasound tissue characterization of
17. Scheerer LJ, Bartolucci L. Ultra sonography in
the cervix and cervical length in the prediction
obstetrics and Gynecology. Ultrasound evaluation
ofpremature delivery
of the cervix. In: Callen PW. 4th ed. Philadelphia:
for
patients
with
spontaneous preterm labor. Am J Obstet Gynecol
2003;189(2): 532-9.
8.
D, Fieni
2013; 208(3): 233-6.
N, Minkoff H. Changes in cervical length and the
7.
Cunningham F, Kenneth L, Steven L, Bloom J,
Eur J Obstet Gynecol Reprod Biol 2006;128(1-2):
Obstet Gynecol Reprod Biol 2010;148(1): 17-20.
6.
9.
women presenting with threatened preterm labor.
short cervix. The LANCET 2004; 363(9424):
4.
-
Rozenberg
P,
W.B. Sounders Company; 2003. 577-83.
18. Naim A, Haberma Sh, Burgess T, Navizedeh N,
Gillet
Transvaginalsonographic
A,
Ville
examination
of
Y.
the
Minkoff H. Changes in cervical length and the
risk ofpreterm labor. Am J Obdtet Gynecol
gestations.
2002;186(5): 887-9.
2001;18(3): 204-10.
Obstet
Gynecol
19. Ghasemi A, Alimohammadian Sh, Davati A.
21. Berghella V, Daly SF, Tolosa JE, DiVito MM,
Relationship between preterm labor and the length
Chalmers R, Garg N, et al. Prediction of
of the cervical canal. Payesh 2006;5(3): 177-84.
pretermdelivery with transvaginal ultrasonography
20. Guzman ER, Walters C, Ananth CV, Benito CW,
Downloaded from umj.umsu.ac.ir at 4:06 IRST on Thursday March 9th 2017
Ultrasound
of
the
cervix
in
patients
with
high-risk
Palermo A,Vintzileos AMcc. A comparison of
pregnancies: does cerclage prevent prematurity.
sonographic cervical parameters in predicting
Am J Obstet Gyneco 1999;181(4): 809-15.
spontaneous preterm birth in high-risk singleton
The Journal of Urmia University of Medical Sciences, Vol. 24(6), August 2013
Original Article
CORRELATION BETWEEN CERVICAL LENGTH BY
TRANSVAGINAL SONOGRAPHY AT16-24WKS OF PREGNANCY
AND PRETERM LABOR
Mohamadjafari R1*,Najafian M2,Vahaby E3,Garibzadeh.S4
Downloaded from umj.umsu.ac.ir at 4:06 IRST on Thursday March 9th 2017
Received: 4 May, 2013; Accepted: 16 Jul, 2013
Abstract
Background & Aims: At least two third of neonatal morbidity and mortality are due to preterm labor.
Transvaginalultrasonography has an important role in diagnosis of cervical incompetency and
prediction of preterm labor. The aim of this study was to determine the value of ultrasonographically
measured cervical length between 16-24 weeks gestation in the prediction of spontaneous preterm
delivery.
Materials & Methods: A prospective cohort study examined cervical length by transvaginal
ultrasonography between 16-24 weeks gestation. A total of 75 women who referred to prenatal clinic
of imam Khomeini and Razi educational hospitals in Ahvaz and met inclusion criteria after measuring
cervical length (c l) by transvaginal ultrasonography (TVS). They included two groups (36 cases with
c l =26-30 m and 40 cases with cl=30-35mm. Then they followed until delivery.
Results: The incidence of preterm labor in c l=26-30 mm was 38% and in group with c l=30-35 mm
was 50%. Respectively, in the multivariate analysis, age, parity, job, education, and cl. There was a
statistically significant relation between cl and preterm birth. (p<0.01)
Conclusion: Mechanical and chemical factors can effect on the cl and cause preterm labor. A short
cervix seen on 16-24 weeks gestation was a strong predictor of preterm birth.
Keywords: Preterm birth, Cervical length, Transvaginal ultrasonography
Address: Fertility Infertility and Perinatology Research Center, Ahvaz Jundishapur University of
Medical Sciences, Ahvaz, Iran Tel: 00989166178041
Email: [email protected]
SOURCE: URMIA MED J 2013: 24(6): 448 ISSN: 1027-3727
1
Associate Professor Obstetrics & Gynecology, Fertility Infertility and Perinatology Research Center, Ahvaz
Jundishapur University of Medical Sciences, Ahvaz, Iran
2
Associate Professor Obstetrics & Gynecology, Fertility Infertility and Perinatology Research Center, Ahvaz
Jundishapur University of Medical Sciences, Ahvaz, Iran
3
Resident of Gynecology and Obstetrics, Department of ob & gyn, Ahvaz Jundishapur University of Medical
Sciences, Ahvaz, Iran
4
Ph.D Student of Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran