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VOL. 761 778 61 NUMBER 5 2009 Review Overview on 5-HT receptors and their role in physiology and pathology of the central nervous system. Ma³gorzata Filip, Michael Bader 877 Enhancement of fibrinolysis by gel-filtered platelets and its quenching by cytochalasin B and GPIIb/IIIa antagonists. Satoru Hoki, Yuko Suzuki, transporters a new strategy for diabetes treatment. Aleksandra Bo³dys, Bogus³aw Okopieñ 885 Possible new organoselenium supplement evaluation of its influence on the kidneys in comparison with inorganic sodium selenite. Review Inhibitors of type 2 sodium glucose co- 785 Characterization of the naturally occurring Arg344His variant of the human 5-HT3A receptor. Sandra Combrink, Arevat Kostanian, Jutta Walstab, Martin Barann, Michael Brüss, Manfred Göthert, Heinz Bönisch 798 Treatment with 1,2,3,4,-tetrahydroisoquinoline affects glutamate release in the striatum but not the binding of [3H]MK-801 to NMDA receptors in the dopaminergic structures of the rat brain. El¿bieta Lorenc-Koci, Krystyna Go³embiowska, Ma³gorzata Pietraszek, Jadwiga Wardas 807 Analgesic activity of 3-mono-substituted derivatives of dihydrofuran-2-one in experimental rodent models of pain. Kinga Sa³at, Barbara Filipek, Krzysztof Wiêckowski, Barbara Malawska 819 Effect of caffeine on the anticonvulsant effects of oxcarbazepine, lamotrigine and tiagabine in a mouse model of generalized tonic-clonic seizures. Magdalena Chrociñska-Krawczyk, Neville Ratnaraj, Philip N. Patsalos, Stanis³aw J. Czuczwar 827 Anti-apoptotic effect of memantine against staurosporine- and low-potassium-induced cell death in cerebellar granule cells: a development-dependent effect. Danuta Jantas, W³adys³aw Lasoñ 838 Commonly used ryanodine receptor activator, 4chloro-m-cresol (4CmC), is also an inhibitor of SERCA Ca2+ pumps. Fawaz Al-Mousa, Francesco Michelangeli 843 Influence of ABCB1 gene polymorphisms on the pharmacokinetics of azithromycin among healthy Chinese Han ethnic subjects. Xiao-Jing He, Li-Mei Zhao, Feng Qiu, Ya-Xin Sun, Jesse Li-Ling 851 Perazine at therapeutic drug concentrations inhibits human cytochrome P450 isoenzyme 1A2 (CYP1A2) and caffeine metabolism an in vitro study. Jacek Wójcikowski, W³adys³awa A. Daniel 859 Effects of ischemia-reperfusion and pretreatment with mildronate on rat liver mitochondrial function. Sonata Trumbeckaitë, Marius Kinèius, Andrius Preidis, Monika Preidienë, Vincentas Veikutis, Vilmantë Borutaitë, Antanas Gulbinas 870 Chronic >-adrenergic activation-induced left ventricular systolic dysfunction is associated with systemic release of TNF-= and IL-1-> in rats. Santosh Kumar, Sandeep Seth, Amardeep Jaiswal, Rajesh Enjamoori, Amit K. Dinda, Ruma Ray, Subir K. Maulik Kazuo Umemura, Tetsumei Urano Irena Musik, Anna Hordyjewska, Anna BoguszewskaCzubara, Kazimierz Pasternak 892 Effect of atorvastatin on paraoxonase1 (PON1) and oxidative status. Amar Nagila, Thinnakorn Permpongpaiboon, Soontharee Tantrarongroj, Pornwalee Porapakkham, Kultira Chinwattana, Sara Deakin, Sureerut Porntadavity 899 Antihyperglycemic effects of ASP8497 in streptozotocin-nicotinamide induced diabetic rats: comparison with other dipeptidyl peptidase-IV inhibitors. Atsuo Tahara, Akiko Matsuyama-Yokono, Ryosuke Nakano, Yuka Someya, Masahiko Hayakawa, Masayuki Shibasaki 909 Effects of high-fat mixed-lipid diet and exercise on the antioxidant system in skeletal and cardiac muscles of rats with colon carcinoma. Martina Pere, Rade Injac, Borut trukelj, Anton Cerar 917 Erythropoietin inhibits liver gelatinases during galactosamine-induced hepatic damage in rats. Agnieszka M¹dro, Jacek Kurzepa, Gra¿yna Czechowska, Maria S³omka, Krzysztof Celiñski, Stanis³awa Szymonik-Lesiuk SHORT COMMUNICATIONS 924 Effect of repeated co-treatment with fluoxetine and amantadine on the behavioral reactivity of the central dopamine and serotonin system in rats. Zofia Rogó¿, Gra¿yna Skuza 930 Lack of effect of sildenafil on cocaine-induced convulsions in mice. Dorota Nieoczym, Katarzyna Soca³a, Piotr Wla 935 Effect of pregnancy and tobacco smoke on the antioxidant activity of rutin in an animal model. Ewa Florek, Ewa Ignatowicz, Wojciech Piekoszewski 941 Effects of N-acetylcysteine and ebselen on arachidonic acid release from astrocytes and neurons cultured in normoxic or simulated ischemic conditions. Natalia Pawlas, Katarzyna Nierwiñska, Anna Stolecka, Bo¿ena Gabryel, Anna Pude³ko, Andrzej Ma³ecki 947 Frequency of common CYP3A5 gene variants in healthy Polish newborn infants. Gra¿yna Adler, Beata £oniewska, Mi³osz Parczewski, Agnieszka Kordek, Andrzej Ciechanowicz 952 Note to Contributors