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453 REVIEW Introduction to in vitro estimation of metabolic stability and drug interactions of new chemical entities in drug discovery and development. 540 Effects of catecholamines on the intramedullary pressure in the femur in rats with prednisolone-induced osteoporosis. Ilona Kaczmarczyk-Sedlak, Urszula Cegie³a, REVIEW Methotrexate in rheumatoid arthritis. 551 Study of the interaction of 1,4-dihydropyridine derivatives with glucocorticoid hormone receptors from . . the rat liver. Aida Vaitkuviene, Audronë Ulinskaite, Rolandas Pawe³ Baranczewski, Andrzej Stañczak, Kathrin Sundberg, Richard Svensson, Åsa Wallin, Jenny Jansson, Per Garberg, Hans Postlind 473 Jerzy wierkot, Jacek Szechiñski 493 Mechanism of synergistic action following co-treatment with pramipexole and fluoxetine or sertraline in the forced swimming test in rats. Zofia Rogó¿, Gra¿yna Skuza 501 Therapeutic tricyclic antidepressant drug monitoring in younger and older depressive patients. Maria Radziwoñ- Zaleska, Halina Matsumoto, Micha³ Skalski, Joanna Wilkowska, Piotr Januszko, Daria Matoszko, Anna Dzikliñska, Bart³omiej Gmaj, Waldemar Szelenberger 507 Serum kynurenic acid positively correlates with cardiovascular disease risk factor, homocysteine: a study in stroke patients. Ewa M. Urbañska, Piotr Luchowski, El¿bieta Luchowska, Jaros³aw Pniewski, Rados³aw Woniak, Ma³gorzata Chodakowska-¯ebrowska, Jerzy Lazarewicz 512 Apoptotic markers in various stages of amygdala kindled seizures in rats. Ma³gorzata Gaw³owicz, Micha³ Reichert, Jacek Wojcierowski Stanis³aw J. Czuczwar, Kinga K. Borowicz 519 Efficacy of bretazenil against cortical epileptic afterdischarges increases during early ontogeny in rats. Pavel Mare, Romana lamberová 526 Comparative study of multiple dosage of quercetin against cisplatin-induced nephrotoxicity and oxidative stress in rat kidneys. Estela B. Behling, Milena C. Sendão, Heloísa D. C. Francescato, Lusânia M. G. Antunes, Roberto S. Costa, Maria de Lourdes P. Bianchi 533 Pharmacological activity of calcimimetic NPS R-568 administered intravenously in rats: dose dependency. Apolonia Rybczyñska, Konrad Boblewski, Artur Lehmann, Czes³awa Orlewska, Henryk Foks Barbara Nowiñska, Joanna Folwarczna Mekys, Gunars Duburs, Vija Klua, Evaldas Liutkevièius SHORT COMMUNICATIONS 559 Trimetazidine increases [!H]glucose uptake in rat brain. Przemys³aw Nowak, Tomasz Zagzi³, Janusz Konecki, Gra¿yna Szczerbak, Ryszard Szkilnik, Janusz Niwiñski, Jaros³aw Gorza³ek, Richard M. Kostrzewa, Ryszard Brus 562 Influence of long-term treatment with tuftsin analogue TP-7 on the anxiety-phobic states and body weight. Ró¿a Czabak-Garbacz, Beata Cygan, £ukasz Wolañski, Igor Kozlovsky 568 Anxiolytic effect of noscapine in mice. Parvin Khodarahmi, Parvin Rostami, Armin Rashidi, Iman Khodarahmi 571 Antepartum/postpartum depressive symptoms and serum zinc and magnesium levels. Jacek Wójcik, Dominika Dudek, Ma³gorzata Schlegel-Zawadzka, Mariola Grabowska, Antoni Marcinek, Ewa Florek, Wojciech Piekoszewski, Rafa³ J. Nowak, W³odzimierz Opoka, Gabriel Nowak 577 Regulation of LDL receptor expression by the effect of curcumin on sterol regulatory element pathway. Chunlei Fan, Xingde Wo, Xiaobing Dou, Li Xu, Ying Qian, Yan Luo, Jin Yan 583 Note to Contributors